The 100 block of East Main Street.

The intersection of West Main Street and Mangum Street. The skyscraper in the background, One City Center, is a 27-story luxury apartment tower completed in 2018.

The 100 block of West Main Street.

The 100 block of West Main Street.

The 21c Museum Hotel Durham is a multi-venue contemporary art museum and full-service boutique hotel. The 125-room boutique hotel opened in 2015 in the history Hill Building. The iconic tower dates back to 1937.

The intersection of West Main and Market Streets.

*The Snow Building is a mixed-use Art Deco building that was completed in 1930. *

Historic storefronts near the intersection of West Main, East Chapel Hill and Morris Streets.

A view of Five Points Plaza.

The Novus is a 27-story condominium and apartment development under construction at 400 West Main Street.

The Museum of Durham History at 500 West Main Street.

Completed in 1987, the 15-story Duke Clinical Research Institute is the third tallest building in Durham.

West Morgan Street in West Village. West Village is a festive mixed-use, pedestrian-oriented adaptive reuse development in the Brightleaf Historic District.

The former Liggett & Myers Tobacco Company manufacturing complex features 375 loft-style apartments, 164,000-square-feet of class A office/lab space and 58,000-square-feet of retail space, a five-story parking structure and an Amtrak Station.

Fuller Street in West Village.

The former offices of Liggett & Myers Tobacco Company at 701 West Main Street.

The intersection of South Gregson Street and West Main Street.

Brightleaf Square is a mixed-use adaptive reuse development occupying tobacco warehouses constructed in 1904 by the American Tobacco Company. The American Tobacco Company was famously broken up in a wave of antitrust reform in 1911.

Brightleaf on Main is a luxury infill apartment community located at 905 West Main Street.

The intersection of West Morgan and West Main Streets.

The Duke University Office of Registrar at 1121 West Main Street.

Article by Ennis Davis, AICP. Contact Ennis at edavis@moderncities.com